When genetic early death seems like a real possibility there is a rude wake up cry for a middle aged person. I figure we only truly have 2,000 useful hours every ten years. So now you understand why people get weird. Sometimes the math kicks in real hard. In my case I have a greater concern and do what I can to avoid an early death, heart attack. I know my risk from having an angina and heart problems in my family. So that changes life.